Fumaric acid-d4

Modify Date: 2024-01-03 20:23:35

Fumaric acid-d4 Structure
Fumaric acid-d4 structure
Common Name Fumaric acid-d4
CAS Number 194160-45-7 Molecular Weight 120.09700
Density N/A Boiling Point N/A
Molecular Formula C4D4O4 Melting Point 299-300ºC (subl.)(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Fumaric acid-d4


Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

 Names

Name dideuterio (E)-2,3-dideuteriobut-2-enedioate
Synonym More Synonyms

 Fumaric acid-d4 Biological Activity

Description Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.  

 Chemical & Physical Properties

Melting Point 299-300ºC (subl.)(lit.)
Molecular Formula C4D4O4
Molecular Weight 120.09700
Exact Mass 120.03600
PSA 74.60000

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Synonyms

Fumaric acid-d4
MFCD00190450