6-Methylflavone

Names

[ Name ]:
6-Methylflavone

[Synonym ]:
6-methyl-2-phenyl-4H-1-benzopyran-4-one
MFCD00017461
2-phenyl-6-methylchromone
6-methyl-flavone
6-Methylflavone

Biological Activity

[Description]:

6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Natural Products >> Flavonoids

Research Areas >> Neurological Disease

[Target]

α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1]

[In Vitro]

6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].

[References]

[1]. Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.208g/cm3

[ Boiling Point ]:
395.5ºC at 760mmHg

[ Melting Point ]:
119-122 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₆H₁₂O₂

[ Molecular Weight ]:
236.26500

[ Flash Point ]:
183.8ºC

[ Exact Mass ]:
236.08400

[ PSA ]:
30.21000

[ LogP ]:
3.76840

[ Vapour Pressure ]:
1.83E-06mmHg at 25°C

[ Index of Refraction ]:
1.623

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%