6-Methylflavone

Modify Date: 2024-01-09 19:42:59

6-Methylflavone Structure
6-Methylflavone structure
Common Name 6-Methylflavone
CAS Number 29976-75-8 Molecular Weight 236.26500
Density 1.208g/cm3 Boiling Point 395.5ºC at 760mmHg
Molecular Formula C16H12O2 Melting Point 119-122 °C (dec.)(lit.)
MSDS N/A Flash Point 183.8ºC

 Use of 6-Methylflavone


6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

 Names

Name 6-methyl-2-phenylchromen-4-one
Synonym More Synonyms

 6-Methylflavone Biological Activity

Description 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
Related Catalog
Target

α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1]

In Vitro 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].
References

[1]. Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.

 Chemical & Physical Properties

Density 1.208g/cm3
Boiling Point 395.5ºC at 760mmHg
Melting Point 119-122 °C (dec.)(lit.)
Molecular Formula C16H12O2
Molecular Weight 236.26500
Flash Point 183.8ºC
Exact Mass 236.08400
PSA 30.21000
LogP 3.76840
Vapour Pressure 1.83E-06mmHg at 25°C
Index of Refraction 1.623

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S26-S36
WGK Germany 3
HS Code 2914399090

 Synthetic Route

 Customs

HS Code 2914399090
Summary 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

6-methyl-2-phenyl-4H-1-benzopyran-4-one
MFCD00017461
2-phenyl-6-methylchromone
6-methyl-flavone
6-Methylflavone
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