Ginkgolide A

Names

[ Name ]:
Ginkgolide A

[Synonym ]:
Ginkgolid A
(1R,3R,7S,8S,10R,11S,13S,16S,17R)-8-tert-Butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione
6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b-dihydroxy-5-methyl-, (3aR,4aR,4bR,5S,7aS,8aS,9R,11S,11aS)-
BN 5202
GINKGOLIDE A,GINKGO BILOBA L
PRIMULIC ACID 1
gingkolide A
ginkolide A
GINKGOBILOBAP.E.
1,7-DIDEOXYGINKGOLIDE C
ginkgolide a from ginkgo biloba leaves
MFCD07437829
GINKGOLIDE A FROM GINKGO LEAVES
GinkgolideA
(1R,3R,7S,8S,10R,11S,13S,16S,17R)-6,17-Dihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione

Biological Activity

[Description]:

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.Target: GABA ReceptorGinkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A significantly shortened the sleeping time induced by anesthetics in mice [1]. Ginkgolide A failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons [2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Natural Products >> Terpenoids and Glycosides

Research Areas >> Inflammation/Immunology

[References]

[1]. Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull, 1993. 16(2): p. 210-2.

[2]. Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
710.1±60.0 °C at 760 mmHg

[ Melting Point ]:
280°C (dec.)

[ Molecular Formula ]:
C₂₀H₂₄O₉

[ Molecular Weight ]:
408.399

[ Flash Point ]:
256.5±26.4 °C

[ Exact Mass ]:
408.142029

[ PSA ]:
128.59000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±5.1 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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