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basmisanil

Names

[ CAS No. ]:
1159600-41-5

[ Name ]:
basmisanil

[Synonym ]:
Methanone, (1,1-dioxido-4-thiomorpholinyl)[6-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-
(1,1-Dioxido-4-thiomorpholinyl)(6-{[3-(4-fluorphenyl)-5-methyl-1,2-oxazol-4-yl]methoxy}-3-pyridinyl)methanon
(1,1-Dioxido-4-thiomorpholinyl)(6-{[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy}-3-pyridinyl)methanone
UNII-788PET5SUA
RG1662
basmisanil
(1,1-dioxo-1λ6-thiomorpholin-4-yl)(6-{[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4- yl]methoxy}pyridin-3-yl)methanone
basmisanilum

Biological Activity

[Description]:

Basmisanil is a highly selective GABAAα5 negative allosteric modulator.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Research Areas >> Neurological Disease

[References]

[1]. Myers JF, et al. Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans. J Cereb Blood Flow Metab. 2016 Jul 27.


[Related Small Molecules]

(+)-Bicuculline | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Riluzole | Baclofen | (R)-Baclofen | Etifoxine | Etomidate | Ginkgolide A | NS-11394 | 5alpha-Pregnan-3alpha-ol-20-one | CGP 52432 | L-655,708 | SAGE-217 | 1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride；SKF89976AHCl

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
726.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H20FN3O5S

[ Molecular Weight ]:
445.464

[ Flash Point ]:
393.2±32.9 °C

[ Exact Mass ]:
445.110779

[ LogP ]:
0.61

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
2-8℃

Related Compounds

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