(+)-Bicuculline
Names
[ CAS No. ]:
485-49-4
[ Name ]:
(+)-Bicuculline
[Synonym ]:
D-BICUCULLINE
EINECS 207-619-7
BICUCULLINE (+)
(+)-Bicuculline
PLUS-BICUCULLINE
bicucculine
(6R)-6-[(5S)-6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
MFCD00005006
Bicuculline
Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-
bicucullin
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
542.3±50.0 °C at 760 mmHg
[ Melting Point ]:
196-198 ºC
[ Molecular Formula ]:
C20H17NO6
[ Molecular Weight ]:
367.352
[ Flash Point ]:
281.8±30.1 °C
[ Exact Mass ]:
367.105591
[ PSA ]:
66.46000
[ LogP ]:
2.88
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.665
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LV0909840
- CHEMICAL NAME :
- Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))-
- CAS REGISTRY NUMBER :
- 485-49-4
- BEILSTEIN REFERENCE NO. :
- 0098786
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H17-N-O6
- MOLECULAR WEIGHT :
- 367.38
- WISWESSER LINE NOTATION :
- T C566 DO FO KN EH&&TJ K1 J- ET B565 CVO JO LO EH KHJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8480 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993- Volume(issue)/page/year: 1,199,1993
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300-H311 + H331-H400
[ Precautionary Statements ]:
P261-P264-P273-P280-P301 + P310-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;N: Dangerous for the environment;
[ Risk Phrases ]:
R23/24/25
[ Safety Phrases ]:
S36/37-S45-S61
[ RIDADR ]:
UN 1544 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
LV0909840
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Nat. Commun. 6 , 6872, (2015)
Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addit...
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.Cell Death Differ. 22 , 1425-36, (2015)
Impairment of synaptic function can lead to neuropsychiatric disorders collectively referred to as synaptopathies. The SNARE protein SNAP-25 is implicated in several brain pathologies and, indeed, bra...
Forebrain NR2B overexpression enhancing fear acquisition and long-term potentiation in the lateral amygdala.Eur. J. Neurosci. 42 , 2214-23, (2015)
N-methyl-d-aspartic acid (NMDA) receptor-dependent long-term potentiation (LTP) at the thalamus-lateral amygdala (T-LA) synapses is the basis for acquisition of auditory fear memory. However, the role...