(R)-Baclofen

Names

[ Name ]:
(R)-Baclofen

[Synonym ]:
(R)-(-)-Baclofen
(βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
Z1YR DG&1VQ &&(R)-(-)- Form
(-)-Baclofen
Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-
(R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid
(3R)-4-Amino-3-(4-chlorophenyl)butyric acid
(3R)-4-Amino-3-(4-chlorophenyl)butanoic acid
(R)-Baclofen
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Arbaclofen
MFCD01321057
(R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid

Biological Activity

[Description]:

(R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Research Areas >> Neurological Disease

[References]

[1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

[2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

[3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

[4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

[5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.3±32.0 °C at 760 mmHg

[ Melting Point ]:
171-174°C

[ Molecular Formula ]:
C₁₀H₁₂ClNO₂

[ Molecular Weight ]:
213.661

[ Flash Point ]:
174.1±25.1 °C

[ Exact Mass ]:
213.055649

[ PSA ]:
63.32000

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
Store at RT

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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