HIV-1 inhibitor-25

Modify Date: 2024-01-17 19:28:33

HIV-1 inhibitor-25 Structure
HIV-1 inhibitor-25 structure
 Common Name HIV-1 inhibitor-25
CAS Number 2475658-74-1 Molecular Weight 433.46
Density N/A Boiling Point N/A
Molecular Formula C26H19N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-25


HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1].

 Names

Name HIV-1 inhibitor-25

 HIV-1 inhibitor-25 Biological Activity

Description HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1].
Related Catalog
Target

HIV (IIIB):13.6 nM (EC50)

HIV-1 (L100I):1.2458 ± 0 μM (EC50)

HIV-1 (K103N):0.4383 ± 0 μM (EC50)

HIV-1 (Y181C):0.5075 ± 0 μM (EC50)

HIV-1 (Y188L):5.8136 ± 2 μM (EC50)

HIV-1 (E138K):0.1961 ± 0 μM (EC50)

HIV-1 (F227L+V106A):3.0683 ± 0 μM (EC50)

References

[1]. Chen X, et al. Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2020;202:112549.

 Chemical & Physical Properties

Molecular Formula C26H19N5O2
Molecular Weight 433.46
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here
Related Compounds: More...
HIV-1 inhibitor-55
2771211-73-3
HIV-1 inhibitor-50
2834087-69-1
HIV-1 inhibitor-31
920036-04-0
HIV-1 inhibitor-52
1818868-23-3
HIV-1 inhibitor-51
2834087-82-8
HIV-1 inhibitor-54
2771211-71-1
HIV-1 inhibitor-47
137448-39-6
HIV-1 inhibitor 18A
331261-50-8
HIV-1 inhibitor-45
2677762-43-3
3,4-dimethoxy-N-((6-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methyl)benzenesulfonamide
2034393-70-7
N-((6-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methyl)-4-(1H-pyrazol-1-yl)benzenesulfonamide
2034370-26-6
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)thiophene-3-carboxamide
2034496-14-3
3-cyano-N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)benzamide
2034537-93-2
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-2-(m-tolyl)acetamide
2034496-24-5
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-2-(4-fluorophenoxy)acetamide
2034537-96-5
2-chloro-N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-6-fluorobenzamide
2034496-30-3
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-3-(2-methoxynaphthalen-1-yl)propanamide
2034392-29-3
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-4-(thiophen-2-yl)benzamide
2034614-95-2
N-(2-(2-(2,5-dioxopyrrolidin-1-yl)ethoxy)ethyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
2034538-52-6
Chemsrc provides HIV-1 inhibitor-25(CAS#:2475658-74-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of HIV-1 inhibitor-25 are included as well.>> amp version: HIV-1 inhibitor-25

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved