Fuberidazole

Fuberidazole Structure
Fuberidazole structure
Common Name Fuberidazole
CAS Number 3878-19-1 Molecular Weight 184.19
Density 1.286g/cm3 Boiling Point 380.6ºC at 760 mmHg
Molecular Formula C11H8N2O Melting Point 310-312℃
MSDS Chinese USA Flash Point 194.7ºC
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.

Bioorg. Med. Chem. Lett. 20 , 4038-44, (2010)

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzym...

Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.

J. Med. Chem. 49 , 511-22, (2006)

We report the discovery of thiabendazole as a potent inhibitor (K(i) = 0.4 microM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range. ...

Quantitative Fusarium spp. and Microdochium spp. PCR assays to evaluate seed treatments for the control of Fusarium seedling blight of wheat.

J. Appl. Microbiol. 102(6) , 1645-53, (2007)

To develop sensitive quantitative PCR assays for the two groups of pathogens responsible for Fusarium seedling blight in wheat: Fusarium group (Fusarium culmorum and Fusarium graminearum) and Microdochium group (Microdochium nivale and Microdochium majus); an...

Possible bitertanol and fuberidazole poisoning in young pheasants.

Vet. Rec. 149(4) , 118-20, (2001)

Determination of benzimidazolic fungicides in fruits and vegetables by supramolecular solvent-based microextraction/liquid chromatography/fluorescence detection.

Anal. Chim. Acta 650(2) , 207-13, (2009)

A supramolecular solvent consisting of vesicles, made up of equimolecular amounts of decanoic acid (DeA) and tetrabutylammonium decanoate (Bu4NDe), dispersed in a continuous aqueous phase, is proposed for the extraction of benzimidazolic fungicides (BFs) from...

Autoradiography in mice of tritiated 2-(2-furyl)benzimidazole and melanin-binding in vitro.

Toxicol. Lett. 17(3-4) , 267-73, (1983)

The distribution of tritiated 2-(2-furyl)benzimidazole ([3H]FB) in male and pregnant albino mice and male pigmented mice was studied by whole-body autoradiography. The most notable finding was the accumulation of radioactivity in the melanin-containing tissue...

Second-order advantage with excitation-emission fluorescence spectroscopy and a flow-through optosensing device. Simultaneous determination of thiabendazole and fuberidazole in the presence of uncalibrated interferences.

Analyst 135(6) , 1299-308, (2010)

This paper presents a novel approach for the simultaneous determination of two widely used fungicides in a very interfering environment, combining the advantage of a spectrofluorimetric optosensor coupled to a flow-injection system and the selectivity of seco...

Trace determination of carbendazim, fuberidazole and thiabendazole in water by application of multivariate calibration to cross-sections of three-dimensional excitation-emission matrix fluorescence.

Analyst 125(6) , 1167-74, (2000)

The simultaneous determination of carbendazim, fuberidazole and thiabendazole was accomplished by cross-section (CS) fluorimetry in combination with multivariate calibration algorithms. The total luminescence information of the compounds was used to optimise ...

Application of GRAM and TLD to the resolution and quantitation of real complex multicomponent mixtures by fluorescence spectroscopy.

Anal. Bioanal. Chem 375(7) , 974-80, (2003)

The application of the generalised rank annihilation method (GRAM) and the trilinear decomposition (TLD) method to the resolution and quantitation of fluorescence excitation-emission matrices of a ternary mixture of pesticides, carbendazim, fuberidazole, and ...

The structure of (S)-(-)-4-(2-benzimidazolyl)-4-hydroxybutyric acid formed during mammalian metabolism of the fungicide 2-(2-furyl)benzimidazole.

Basic Clin Pharmacol Toxicol. 96(4) , 325-30, (2005)

During metabolism of the fungicide 2-(2-furyl)benzimidazole (FB) in mammals, an optically active compound, metabolite A, was isolated. This compound, a principal metabolite in the biological degradation of FB, was isolated from the urine of horse and dog. Whe...