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3878-19-1

3878-19-1 structure
3878-19-1 structure
  • Name: Fuberidazole
  • Chemical Name: fuberidazole
  • CAS Number: 3878-19-1
  • Molecular Formula: C11H8N2O
  • Molecular Weight: 184.19
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2018-09-19 16:31:51
  • Modify Date: 2025-08-24 19:58:16
  • Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea[1].
Name fuberidazole
Synonyms Fubridazole
EINECS 223-404-0
2-(2-Furanyl)-1H-benzimidazole
2-(furan-2-yl)-benzimidazole
2-(furan-2-yl)-1H-benzo[d]imidazole
Benzimidazole,2-(2-furyl)
2-(furan-2-yl)-1H-benzimidazole
Fuberidatol
2-(2'-furyl)-benzimidazole
Voronite
Fuberidazol
Furidazole
Furidazol
MFCD00055496
2-(2-furyl)benzimidazole
Fuberisazol
2-(furan-2-yl)-1H-1,3-benzimidazole
2-(2'-furyl)-1H-benzimidazole
Voronit
Description Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea[1].
Related Catalog
Target

B. cinerea[1]

In Vitro Fuberidazole (FBZ) (10 μM) 在 CB8 (100 μM) 存在的情况下表现出 1.4 个单位的 pKa 偏移[1]。 Fuberidazole (10-200 μM; 72 h) 对灰霉病菌 (B. cinerea) 表现出增加的生长抑制率。与 CB7/CB8 结合的 Fuberidazole 对 B. cinerea 的生长至少是 Fuberidazole 单独抑制 3 倍[1]。
References

[1]. Saleh N, et al. Enhancement of in vitro fungicidal activity of fuberidazole to Botrytis cinerea by cucurbiturils. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 79: 301-309.

Density 1.286g/cm3
Boiling Point 380.6ºC at 760 mmHg
Melting Point 310-312℃
Molecular Formula C11H8N2O
Molecular Weight 184.19
Flash Point 194.7ºC
Exact Mass 184.06400
PSA 41.82000
LogP 2.82290
Index of Refraction 1.67

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD9010000
CHEMICAL NAME :
Benzimidazole, 2-(2-furyl)-
CAS REGISTRY NUMBER :
3878-19-1
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C11-H8-N2-O
MOLECULAR WEIGHT :
184.21
WISWESSER LINE NOTATION :
T56 BM DNJ C- BT5OJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
330 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 15,273,1972 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H311-H317-H330-H351-H373-H410
Precautionary Statements P260-P273-P280-P284-P304 + P340 + P310-P403 + P233
Target Organs Heart
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn,N
Risk Phrases R22:Harmful if swallowed. R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
Safety Phrases S22-S60-S61
RIDADR 2588
WGK Germany 3.0
RTECS DD9010000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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