Arbidol HCl
Arbidol HCl structure
|
Common Name | Arbidol HCl | ||
|---|---|---|---|---|
| CAS Number | 131707-23-8 | Molecular Weight | 513.875 | |
| Density | N/A | Boiling Point | 591.8ºC at 760 mmHg | |
| Molecular Formula | C22H26BrClN2O3S | Melting Point | 133-137ºC | |
| MSDS | Chinese USA | Flash Point | 311.7℃ | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
[Potentiation of NO-dependent activation of soluble guanylyl cyclase by 5-nitroisatin and antiviral preparatation arbidol].
Biomed. Khim. 59(3) , 295-304, (2013) Isatin (indole-dione) is an endogenous indole that exibits a wide range of biological and physiological activity. The influence of isatin derivatives 5-nitroisatin and arbidol (an antiviral preparatation) on spermine NONO-induced activation of human platelet ... |
|
|
Arbidol exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.
Pharmazie 68(12) , 945-50, (2013) The aim of the present study was to investigate arbidol's inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. The nonspecific probe substrate 4-methylumbelliferone (4-MU) and recombinant UGT enzymes (UGT1A9, UGT2B7) were firstly used to evaluate... |
|
|
Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans.
Antimicrob. Agents Chemother. 57(4) , 1743-55, (2013) Arbidol is a broad-spectrum antiviral drug that is used clinically to treat influenza. In this study, the pharmacokinetics, metabolism, and excretion of arbidol were investigated in healthy male Chinese volunteers after a single oral administration of 200 mg ... |
|
|
Glucuronidation of the broad-spectrum antiviral drug arbidol by UGT isoforms.
J. Pharm. Pharmacol. 65(4) , 521-7, (2013) The aim of this work was to identify the uridine glucuronosyltransferase (UGT) isoforms involved in the metabolism of the broad-spectrum antiviral drug arbidol.A human liver microsome (HLM) incubation system was employed to catalyse the formation of arbidol g... |
|
|
Membranotropic effects of arbidol, a broad anti-viral molecule, on phospholipid model membranes.
J. Phys. Chem. B 114(25) , 8544-54, (2010) Arbidol, a broad and potent antiviral molecule, incorporates rapidly into membranes. To gain further insight into the mode of action of Arbidol, since the exact antiviral mechanism of Arbidol is unknown, I examined its interaction and effects on model membran... |
|
|
Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro.
Bioorg. Med. Chem. 18(16) , 6143-8, (2010) A series of ethyl 1H-indole-3-carboxylates 9a(1)(-)(6) and 9b(1)(-)(2) were prepared and evaluated in Huh-7.5 cells. Most of the compounds exhibited anti-hepatitis C virus (HCV) activities at low concentration. The selectivity indices of inhibition on entry a... |
|
|
A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats.
Drug Chem. Toxicol. 33(3) , 244-53, (2010) The antiviral drug combination consisting of arbidol and acetaminophen was investigated for its 4-week repeated oral administration in Sprague-Dawley rats. Groups of rats (10/sex in low-dose group, 15/sex in other three groups) were given at doses of 0, 200, ... |
|
|
High-performance liquid chromatography/tandem mass spectrometry method for the determination of arbidol in human plasma.
J. AOAC Int. 94(4) , 1100-5, (2011) An HPLC/MS/MS method for the determination of arbidol in human plasma was developed. Arbidol and internal standard (loratadine) were extracted from alkaline plasma with tert-butyl methyl ether and analyzed on a Zorbax SB C18 column (30 x 2.1 mm id, 3.5 microm... |
|
|
Pharmacokinetics of single and multiple oral doses of arbidol in healthy Chinese volunteers.
Int. J. Clin. Pharmacol. Ther. 51(5) , 423-32, (2013) Arbidol is licensed in Russia and China for prophylaxis and treatment of influenza A and B. This study was to assess the pharmacokinetics of single and multiple doses of arbidol in healthy Chinese volunteers.This was a single-center, open-label, two-phase stu... |
|
|
Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol.
PLoS ONE 6(1) , e15874, (2011) The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane. To better understand Arb mechanism of action, we investigated its interactions with phospholipids and membrane peptides. We d... |