Cyclen
Cyclen structure
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Common Name | Cyclen | ||
|---|---|---|---|---|
| CAS Number | 294-90-6 | Molecular Weight | 172.27 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 283.8±8.0 °C at 760 mmHg | |
| Molecular Formula | C8H20N4 | Melting Point | 110-113 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 129.5±13.5 °C | |
| Symbol |
GHS05, GHS07, GHS09 |
Signal Word | Danger | |
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Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.
Bioorg. Med. Chem. Lett. 18 , 169-74, (2008) Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non-pep... |
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Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation.
Inorg. Chem. 51(12) , 6916-27, (2012) The syntheses of a new 1,4,7,10-tetraazacyclododecane (cyclen) derivative bearing a picolinate pendant arm (HL1), and its 1,4,8,11-tetraazacyclotetradecane (cyclam) analogue HL2, were achieved by using two different selective-protection methods involving the ... |
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Copper and cobalt complexes of octadentate azamacrocycles: spectrophotometric titration, stopped-flow kinetics and crystallographic study.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 525-31, (2011) Details of complex formation kinetics are reported for tetrakis(2-hydroxyethyl) substituted cyclen (L(1)) and cyclam (L(2)) with Cu(II) and Co(II). Stopped-flow kinetics and spectroscopic titration methods were employed for the activation parameters and stabi... |
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Quantification and visualization of glutathione S-transferase omega 1 in cells using inductively coupled plasma mass spectrometry (ICP-MS) and fluorescence microscopy.
Anal. Bioanal. Chem 407(9) , 2373-81, (2015) We report a novel activity-based and Cu-free click chemistry (CC) mediated methodology for glutathione S-transferase omega 1 (GSTO1) quantification using species-unspecific isotope dilution inductively coupled plasma mass spectrometry (SUID ICP-MS), in which ... |
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A neutral polydisulfide containing Gd(III) DOTA monoamide as a redox-sensitive biodegradable macromolecular MRI contrast agent.
Contrast Media Mol. Imaging 11 , 32-40, (2016) This work aims to develop safe and effective gadolinium (III)-based biodegradable macromolecular MRI contrast agents for blood pool and cancer imaging. A neutral polydisulfide containing macrocyclic Gd-DOTA monoamide (GOLS) was synthesized and characterized. ... |
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New trick for an old ligand! The sensing of Zn(II) using a lanthanide based ternary Yb(III)-cyclen-8-hydroxyquinoline system as a dual emissive probe for displacement assay.
Inorg. Chem. 51(19) , 10158-68, (2012) A novel near-infrared (NIR) emissive lanthanide-based zinc sensor was designed, based on the self-assembly in aqueous solution between the nonemissive coordinatively unsaturated Yb(III) cyclen complex 2·Yb and the sulfonated 8-hydroxyquinoline (8-HQS) chromop... |
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Molecular recognition of hydrocarbon guests by a supramolecular capsule formed by the 4:4 self-assembly of tris(Zn(2+)-cyclen) and trithiocyanurate in aqueous solution.
Chem. Asian J. 7(5) , 944-56, (2012) We have previously reported that the trimeric Zn(2+)-cyclen complex (tris(Zn(2+)-cyclen), [Zn(3)L(1)](6+)) and the trianion of trithiocyanuric acid (TCA(3-)) assembled in a 4:4 ratio to form a cuboctahedral supramolecular cage, [(Zn(3)L(1))(4)(TCA(3-))(4)](12... |
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Vesicles and micelles from amphiphilic zinc(II)-cyclen complexes as highly potent promoters of hydrolytic DNA cleavage.
J. Am. Chem. Soc. 133(51) , 20704-7, (2011) Phosphate esters are essential to any living organism and their specific hydrolysis plays an important role in many metabolic processes. As phosphodiester bonds can be extraordinary stable, as in DNA, great effort has been put into mimicking the active sites ... |
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Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine.
Bioorg. Med. Chem. Lett. 21(19) , 5866-5869, (2011) In this report we describe the synthesis of a new class of cyclen-contained compounds with novel peptide nucleic acid (PNA) analog motif. Target bis-cyclen derivative B was prepared and characterized by ESI-MS, NMR and HPLC. Interactions between compound B an... |
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Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens.
Dalton Trans. 42(13) , 4357-60, (2013) The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N). |