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294-90-6

294-90-6 structure
294-90-6 structure
  • Name: Cyclen
  • Chemical Name: 1,4,7,10-tetraazacyclododecane
  • CAS Number: 294-90-6
  • Molecular Formula: C8H20N4
  • Molecular Weight: 172.27
  • Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
  • Create Date: 2018-09-24 18:43:25
  • Modify Date: 2025-08-21 18:13:20
  • Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].
Name 1,4,7,10-tetraazacyclododecane
Synonyms Tetraaza-12-crown-4
T-12-M DM GM JMTJ
Cyclen
1,4,7,10-tetrazacyclododecane
MFCD00066281
1,4,7,10-Tetraazacyclododecane
5-26-11-00023 (Beilstein Handbook Reference)
[12]aneN4
1,4,7,12-tetraazacyclodedecane
EINECS 202-928-3
Description Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].
Related Catalog
References

[1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.
Density 0.9±0.1 g/cm3
Boiling Point 283.8±8.0 °C at 760 mmHg
Melting Point 110-113 °C(lit.)
Molecular Formula C8H20N4
Molecular Weight 172.27
Flash Point 129.5±13.5 °C
Exact Mass 172.168793
PSA 48.12000
LogP -2.34
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.424
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XA5253000
CHEMICAL NAME :
1,4,7,10-Tetraazacyclododecane
CAS REGISTRY NUMBER :
294-90-6
BEILSTEIN REFERENCE NO. :
0606114
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H20-N4
MOLECULAR WEIGHT :
172.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
388 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 70,201,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
435 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,425,1984
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H302-H312-H314-H410
Precautionary Statements P273-P280-P305 + P351 + P338-P310-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XA5253000
Packaging Group I; II; III
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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