Dalton Transactions (Print Edition) 2013-04-07

Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens.

Jan Hormann, Chrischani Perera, Naina Deibel, Dieter Lentz, Biprajit Sarkar, Nora Kulak

Index: Dalton Trans. 42(13) , 4357-60, (2013)

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Abstract

The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).