Bioorganic & Medicinal Chemistry Letters 2008-01-01

Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.

Amandine Rolland, Isabelle Boquet, Jean-Chrétien Norreel, Vincent Moret, Younes Laras, Jean-Louis Kraus

Index: Bioorg. Med. Chem. Lett. 18 , 169-74, (2008)

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Abstract

Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non-peptidic disulfide derivative 8 significantly decreases the migration of neuroblasts from SVZ cells, and antagonized the stimulating activity of disulfide cyclic peptide 1. Discovery of compounds 1 and 8 constitutes new chemical tools which could be used to understand the mechanism of neuroblast migration during neurogenesis and eventually to identify specific genes involved in the neurogenesis.