25-Hydroxycholesterol
25-Hydroxycholesterol structure
|
Common Name | 25-Hydroxycholesterol | ||
|---|---|---|---|---|
| CAS Number | 2140-46-7 | Molecular Weight | 402.653 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 213.5±17.2 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
|
Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT ass... |
|
|
The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols.
J. Pharmacol. Sci. 127(3) , 251-9, (2015) Variant pharmacological activities of Zanthoxylum bungeanum were determined before. The aim of this study was to assess whether Z. bungeanum could regulate lipid metabolism. The cholesterol overloading HepG2 cells induced by sterols were used as in vitro mode... |
|
|
Specific cellular incorporation of a pyrene-labelled cholesterol: lipoprotein-mediated delivery toward ordered intracellular membranes.
PLoS ONE 10(4) , e0121563, (2015) In the aim of testing tools for tracing cell trafficking of exogenous cholesterol, two fluorescent derivatives of cholesterol, 22-nitrobenzoxadiazole-cholesterol (NBD-Chol) and 21-methylpyrenyl-cholesterol (Pyr-met-Chol), with distinctive chemico-physical cha... |
|
|
Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells.
Biochem. Pharmacol. 96 , 119-30, (2015) Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particu... |
|
|
Oxidative stability of n-3-enriched chicken patties under different package-atmosphere conditions.
Food Chem. 168 , 372-82, (2015) The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the s... |
|
|
Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.
J. Biol. Chem. 290 , 20565-79, (2015) Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a nove... |
|
|
A candidate reference measurement procedure for quantifying serum concentrations of 25-hydroxyvitamin D₃ and 25-hydroxyvitamin D₂ using isotope-dilution liquid chromatography-tandem mass spectrometry.
Anal. Bioanal. Chem 407 , 5615-24, (2015) The inaccuracy of routine serum 25-hydroxyvitamin D measurements hampers the interpretation of data in patient care and public health research. We developed and validated a candidate reference measurement procedure (RMP) for highly accurate quantitation of tw... |
|
|
Effects of progesterone and norethindrone on female fathead minnow (Pimephales promelas) steroidogenesis.
Environ. Toxicol. Chem. 34(2) , 379-90, (2015) As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (... |
|
|
Detection of dihydroxycholesterols in human plasma using HPLC-ESI-MS/MS.
Steroids 99 , 131-8, (2015) We report a straightforward sample preparation procedure and a direct liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the analysis of 7alpha,25-dihydroxycholesterol (7α25-OHC) and 7alpha,27-dihydroxycholesterol... |
|
|
Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation.
J. Inflamm. (Lond.) 12 , 15, (2015) Atherosclerosis, the underlying cause of heart attack and strokes, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atheros... |