2140-46-7

2140-46-7 structure

Name: 25-Hydroxycholesterol
Chemical Name: 25-hydroxycholesterol
CAS Number: 2140-46-7
Molecular Formula: C₂₇H₄₆O₂
Molecular Weight: 402.653
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-02-16 08:00:00
Modify Date: 2025-08-21 18:07:35
25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

Name	25-hydroxycholesterol
Synonyms	25-Hydroxy Cholesterol (3β,9β,14β)-Cholest-5-ene-3,25-diol Cholest-5-ene-3,25-diol, (3β,9β,14β)- (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

Description	25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Related Catalog	Research Areas >> Inflammation/Immunology Natural Products >> Steroids
Target	Human Endogenous Metabolite
In Vitro	The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].
References	[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335-H373
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-36/37/38-48
Safety Phrases	26-36-45
RIDADR	NONH for all modes of transport