25-Hydroxycholesterol

Modify Date: 2025-08-21 18:07:35

25-Hydroxycholesterol structure	Common Name	25-Hydroxycholesterol
	CAS Number	2140-46-7	Molecular Weight	402.653
	Density	1.0±0.1 g/cm3	Boiling Point	513.1±23.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₆O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	213.5±17.2 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of 25-Hydroxycholesterol

25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

Name	25-hydroxycholesterol
Synonym	More Synonyms

Description	25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Related Catalog	Research Areas >> Inflammation/Immunology Natural Products >> Steroids
Target	Human Endogenous Metabolite
In Vitro	The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].
References	[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

Density	1.0±0.1 g/cm3
Boiling Point	513.1±23.0 °C at 760 mmHg
Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.653
Flash Point	213.5±17.2 °C
Exact Mass	402.349792
PSA	40.46000
LogP	7.66
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.538
Storage condition	2-8℃

25-Hydroxycholesterol MSDS(Chinese)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335-H373
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-36/37/38-48
Safety Phrases	26-36-45
RIDADR	NONH for all modes of transport

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