CP-96345
CP-96345结构式
|
常用名 | CP-96345 | 英文名 | CP-96345 |
|---|---|---|---|---|
| CAS号 | 132746-60-2 | 分子量 | 412.57 | |
| 密度 | 1.15g/cm3 | 沸点 | 541.5ºC at 760 mmHg | |
| 分子式 | C28H32N2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 281.3ºC | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
CP-96345用途CP-96345是一种特异、高效、口服活性的速激肽和P物质受体非肽抑制剂。CP-96345可防止P物质和神经激肽A引起的血压下降。CP-96345可用于研究神经源性炎症[1]。 |
| 英文名 | (2S,3S)-2-benzhydryl-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine |
|---|---|
| 英文别名 | 更多 |
| 描述 | CP-96345是一种特异、高效、口服活性的速激肽和P物质受体非肽抑制剂。CP-96345可防止P物质和神经激肽A引起的血压下降。CP-96345可用于研究神经源性炎症[1]。 |
|---|---|
| 相关类别 | |
| 靶点 |
Tachykinin, Substance P receptor[1] |
| 参考文献 |
| 密度 | 1.15g/cm3 |
|---|---|
| 沸点 | 541.5ºC at 760 mmHg |
| 分子式 | C28H32N2O |
| 分子量 | 412.57 |
| 闪点 | 281.3ºC |
| 精确质量 | 412.25100 |
| PSA | 24.50000 |
| LogP | 5.40850 |
| InChIKey | FLNYLINBEZROPL-NSOVKSMOSA-N |
| SMILES | COc1ccccc1CNC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 |
| 蒸汽压 | 8.65E-12mmHg at 25°C |
| 折射率 | 1.633 |
| 储存条件 | -20°C |
| 符号 |
GHS07, GHS09 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H315-H319-H335-H400 |
| 警示性声明 | P261-P273-P305 + P351 + P338 |
| 危害码 (欧洲) | Xi |
| 危险品运输编码 | UN 3077 9 / PGIII |
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Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
Br. J. Pharmacol. 172(3) , 924-39, (2015) Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr... |
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Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008) This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str... |
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An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
Am. J. Pathol. 169(5) , 1663-70, (2006) Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p... |
| (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine |
| CP 96,345 |
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