CP-96345
CP-96345 structure
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Common Name | CP-96345 | ||
|---|---|---|---|---|
| CAS Number | 132746-60-2 | Molecular Weight | 412.57 | |
| Density | 1.15g/cm3 | Boiling Point | 541.5ºC at 760 mmHg | |
| Molecular Formula | C28H32N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 281.3ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of CP-96345CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1]. |
| Name | (2S,3S)-2-benzhydryl-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine |
|---|---|
| Synonym | More Synonyms |
| Description | CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1]. |
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| Related Catalog | |
| Target |
Tachykinin, Substance P receptor[1] |
| References |
| Density | 1.15g/cm3 |
|---|---|
| Boiling Point | 541.5ºC at 760 mmHg |
| Molecular Formula | C28H32N2O |
| Molecular Weight | 412.57 |
| Flash Point | 281.3ºC |
| Exact Mass | 412.25100 |
| PSA | 24.50000 |
| LogP | 5.40850 |
| Vapour Pressure | 8.65E-12mmHg at 25°C |
| Index of Refraction | 1.633 |
| Storage condition | -20°C |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335-H400 |
| Precautionary Statements | P261-P273-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | UN 3077 9 / PGIII |
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Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
Br. J. Pharmacol. 172(3) , 924-39, (2015) Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr... |
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Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008) This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str... |
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An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
Am. J. Pathol. 169(5) , 1663-70, (2006) Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p... |
| (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine |
| CP 96,345 |