CP-96345
CP-96345 structure
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Common Name | CP-96345 | ||
|---|---|---|---|---|
| CAS Number | 132746-60-2 | Molecular Weight | 412.57 | |
| Density | 1.15g/cm3 | Boiling Point | 541.5ºC at 760 mmHg | |
| Molecular Formula | C28H32N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 281.3ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
Br. J. Pharmacol. 172(3) , 924-39, (2015) Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administration of the P/Q- and N-type VGCC blockers Tx3-3 and Phα1β,... |
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Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008) This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative stress) following oil smoke exposure (OSE) in rats; and 2) det... |
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An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
Am. J. Pathol. 169(5) , 1663-70, (2006) Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or precipitated withdrawal (PW) potentiates human immunodeficie... |
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Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist--a putative role for substance P in CNS inflammation.
J. Neuroimmunol. 179(1-2) , 1-8, (2006) Substance P (SP) is an excitatory neurotransmitter in the central and peripheral nervous system. Most of its physiological functions are mediated through binding to the neurokinin-1 receptor (NK-1R). Recently, proinflammatory properties of SP have been descri... |
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Colorectal distension enforce acute urinary bladder distension-induced hepatic vasoconstriction in the rat.
Neurosci. Lett. 443(3) , 257-60, (2008) Acute urinary bladder distension (AUBD) and colorectal distension (CRD) activated mechanical afferents from the urinary bladder and colon and the activated afferent signaling affected visceral organ behavior. AUBD and CRD have been reported to affect the arte... |
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Attenuation of the gerbil writhing response by mu-, kappa- and delta-opioids, and NK-1, -2 and -3 receptor antagonists.
Pharmacol. Biochem. Behav. 79(1) , 125-35, (2004) Mu-, kappa- and delta-opioid receptor agonists are reported to attenuate the acetic-acid-induced abdominal constriction response in mice. NK-1, -2 and -3 receptor antagonists also display activity in several visceral pain models. As the gerbil NK-1 receptor i... |
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A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons.
J. Neurosci. Res. 75(4) , 544-53, (2004) Opioids and the neuropeptide substance P (SP) modulate the expression of inflammatory cytokines and chemokines, which are under the control of nuclear factor kappaB (NF-kappaB). We investigated whether the neurokinin-1 receptor (SP receptor) pathway is biolog... |
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Substance P antagonist CP-96345 blocks lung vascular leakage and inflammation more effectively than its stereoisomer CP-96344 in a mouse model of smoke inhalation and burn injury.
Toxicol. Mech. Methods 20(4) , 197-203, (2010) The recently developed murine model of smoke inhalation and burn (SB) injury was used to study the effect of the substance-P antagonist CP96345. C57BL/6 mice were pre-treated with an i.v. dose of a specific NK-1 receptor antagonist, CP9635, or its inactive en... |
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Substance P potentiates TGFbeta-1 production in lung epithelial cell lines.
Iran. J. Allergy. Asthma. Immunol. 8(1) , 19-24, (2009) Transforming growth factor-beta (TGF-beta) is one of the most important cytokines implicated in growth, differentiation, repair and also the pathogenesis of the lung fibrosis by its stimulatory effect on extracellular matrix deposition. Pulmonary epithelial c... |
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Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.
Am. J. Physiol. Lung Cell. Mol. Physiol. 291(5) , L896-904, (2006) We have shown earlier that H(2)S acts as a mediator of inflammation. In this study, we have investigated the involvement of substance P and neurogenic inflammation in H(2)S-induced lung inflammation. Intraperitoneal administration of NaHS (1-10 mg/kg), an H(2... |