478341-55-8
478341-55-8 structure
- Name: CP-339818 hydrochloride
- Chemical Name: CP-339818
- CAS Number: 478341-55-8
- Molecular Formula: C21H25ClN2
- Molecular Weight: 340.890
- Create Date: 2020-01-11 19:18:58
- Modify Date: 2024-01-14 14:02:44
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CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM; displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)); inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation.
| Name | CP-339818 |
|---|---|
| Synonyms |
(4E)-1-Benzyl-N-pentyl-4(1H)-quinolinimine hydrochloride (1:1)
1-Pentanamine, N-[(4E)-1-(phenylmethyl)-4(1H)-quinolinylidene]-, hydrochloride (1:1) MFCD19053250 CP-339818 N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride MFCD09878238 |
| Description | CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM; displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)); inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation. |
|---|---|
| References | References 1. Nguyen A, et al. Mol Pharmacol. 1996 Dec;50(6):1672-9. 2. Jäger H, et al. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301. 3. Lee YT, et al. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. View Related Products by Target Potassium Channel |
| Molecular Formula | C21H25ClN2 |
|---|---|
| Molecular Weight | 340.890 |
| Exact Mass | 340.170624 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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