212790-31-3

• 常用中文名：CP-481715
• 常用英文名：CP-481715
• CAS号：212790-31-3
• 分子式：C₂₆H₃₁FN₄O₄
• 分子量：482.54700
• 发布时间：2017-10-07 06:17:33
• 更新时间：2025-08-20 19:37:27
• CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity and .

名称

• 英文名: N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide
• 英文别名: cp-481,715

物化性质

• 分子式: C₂₆H₃₁FN₄O₄
• 分子量: 482.54700
• 精确质量: 482.23300
• PSA: 142.91000
• LogP: 4.23810

合成路线

624736-64-7 ~% 212790-31-3

文献：Brown, Matthew F.; Avery, Mike; Brissette, William H.; Chang; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P.; Gladue, Ronald P.; Kath, John C.; Krueger, Suzanne S.; Lira, Paul D.; Lillie, Brett M.; Lundquist, Greg D.; Mairs, Erin N.; McElroy, Eric B.; McGlynn, Molly A.; Paradis, Timothy J.; Poss, Christopher S.; Rossulek, Michelle I.; Shepard, Richard M.; Sims, Jeff; Strelevitz, Timothy J.; Truesdell, Susan; Tylaska, Laurie A.; Yoon, Kwansik; Zheng, Deye Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2175 - 2179

870-63-3 ~% 212790-31-3

文献：Li, Bryan; Andresen, Brian; Brown, Matthew F.; Buzon, Richard A.; Chiu, Charles K.-F.; Couturier, Michel; Dias, Eric; Urban, Frank J.; Jasys, V. John; Kath, John C.; Kissel, William; Le, Tung; Li, Z. Jane; Negri, Joanna; Poss, Christopher S.; Tucker, John; Whritenour, David; Zandi, Kathleen Organic Process Research and Development, 2005 , vol. 9, # 4 p. 466 - 471

54745-92-5 ~% 212790-31-3

文献：Brown, Matthew F.; Avery, Mike; Brissette, William H.; Chang; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P.; Gladue, Ronald P.; Kath, John C.; Krueger, Suzanne S.; Lira, Paul D.; Lillie, Brett M.; Lundquist, Greg D.; Mairs, Erin N.; McElroy, Eric B.; McGlynn, Molly A.; Paradis, Timothy J.; Poss, Christopher S.; Rossulek, Michelle I.; Shepard, Richard M.; Sims, Jeff; Strelevitz, Timothy J.; Truesdell, Susan; Tylaska, Laurie A.; Yoon, Kwansik; Zheng, Deye Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2175 - 2179

1026721-04-9 ~% 212790-31-3

文献：Brown, Matthew F.; Avery, Mike; Brissette, William H.; Chang; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P.; Gladue, Ronald P.; Kath, John C.; Krueger, Suzanne S.; Lira, Paul D.; Lillie, Brett M.; Lundquist, Greg D.; Mairs, Erin N.; McElroy, Eric B.; McGlynn, Molly A.; Paradis, Timothy J.; Poss, Christopher S.; Rossulek, Michelle I.; Shepard, Richard M.; Sims, Jeff; Strelevitz, Timothy J.; Truesdell, Susan; Tylaska, Laurie A.; Yoon, Kwansik; Zheng, Deye Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2175 - 2179

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