顺丁烯二甲酸二甲酯
顺丁烯二甲酸二甲酯结构式
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常用名 | 顺丁烯二甲酸二甲酯 | 英文名 | dimethyl maleate |
|---|---|---|---|---|
| CAS号 | 624-48-6 | 分子量 | 144.125 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 193.0±0.0 °C at 760 mmHg | |
| 分子式 | C6H8O4 | 熔点 | -17ºC | |
| MSDS | 中文版 美版 | 闪点 | 91.1±0.0 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.
PLoS ONE 9(6) , e98385, (2014) Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon doub... |
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Sensitization to dimethyl fumarate with multiple concurrent patch test reactions.
Contact Dermatitis 62(2) , 88-96, (2010) Chairs and sofas imported from China to Europe were shown to contain dimethyl fumarate (DMF), a sensitizing, volatile chemical. Many of the sensitized patients also had positive patch test reactions to acrylates.To analyse the occurrence and strength of DMF s... |
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Use of p-nitrophenyl disulfide to measure reductive capacity of intact cells.
Meth. Enzymol. 251 , 279-86, (1995)
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Maleic acid dimethylester: evaluation of dermal toxicity and genotoxicity.
Food Chem. Toxicol. 29(8) , 575-8, (1991) Maleic acid dimethylester (MAD) was investigated in acute and subacute dermal toxicity studies, for sensitization potential, and for in vivo and in vitro genotoxicity. The acute dermal toxicity in rats was low (LD50 greater than 2000 mg/kg body weight). Only ... |
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Experimental and computational evidence for alpha-lactone intermediates in the addition of aqueous bromine to disodium dimethyl-maleate and -fumarate.
Org. Biomol. Chem. 5(24) , 4001-9, (2007) Structural analysis of the bromo-beta-lactones obtained by addition of bromine to aqueous solutions of disodium 2,3-dimethylmaleate and 2,3-dimethylfumarate reveals stereochemistries opposite to those originally assigned in 1937: cis alkene yields erythro lac... |
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Facile synthesis of oxabicyclic alkenes by ultrasonication-promoted diels-alder cycloaddition of furano dienes.
J. Org. Chem. 69(17) , 5763-5, (2004) Ultrasonic irradiation effectively promotes the Diels-Alder reaction of substituted furans with reactive dienophiles (i.e., dimethyl acetylenedicarboxylate (DMAD) and dimethyl maleate). Regiospecific furano Diels-Alder cycloaddition of 2-vinylic furans with D... |
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Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
Teratology 40(2) , 127-41, (1989) The teratogenicity of phenytoin may result from its enzymatic bioactivation to a reactive intermediate, which, if not detoxified, can interact with embryonic tissues and alter development. Glutathione (GSH) is an important cofactor/substrate for many physiolo... |
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Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides.
J. Am. Chem. Soc. 124(45) , 13400-1, (2002) A highly reactive Ag(I)-catalyzed [3 + 2] cycloaddition of azomethine ylides is founded using AgOAc as the catalytic precursor and phosphines as ligands. Using a new bis-ferrocenyl amide phosphine (FAP) as the ligand, we found that high enantioselectivities (... |
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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).
Proc. Natl. Acad. Sci. U. S. A. 99(5) , 2708-13, (2002) Cellular metabolism of glucose is required for stimulation of insulin secretion from pancreatic beta cells, but the precise metabolic coupling factors involved in this process are not known. In an effort to better understand mechanisms of fuel-mediated insuli... |
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The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors.
Methods Find. Exp. Clin. Pharmacol. 19(3) , 147-51, (1997) Menadione and dimethyl maleate, Michael reaction acceptors, induced N-ethylmaleimide (NEM) reductase activity in Escherichia coli strain DH5a. Linoleic acid also induced NEM reductase activity, but oleic acid, which is less susceptible to lipid peroxidation t... |