dimethyl maleate

Modify Date: 2025-08-20 13:43:11

dimethyl maleate structure	Common Name	dimethyl maleate
	CAS Number	624-48-6	Molecular Weight	144.125
	Density	1.1±0.1 g/cm3	Boiling Point	193.0±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₈O₄	Melting Point	-17ºC
	MSDS	Chinese USA	Flash Point	91.1±0.0 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Name	dimethyl maleate
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	193.0±0.0 °C at 760 mmHg
Melting Point	-17ºC
Molecular Formula	C₆H₈O₄
Molecular Weight	144.125
Flash Point	91.1±0.0 °C
Exact Mass	144.042252
PSA	52.60000
LogP	0.62
Vapour Pressure	0.5±0.3 mmHg at 25°C
Index of Refraction	1.435
Stability	Stable. Combustible. Incompatible with acids, bases, reducing agents, strong oxidizing agents.

dimethyl maleate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM6300000

CHEMICAL NAME :: 2-Butenedioic acid, dimethyl ester, (Z)-

CAS REGISTRY NUMBER :: 624-48-6

BEILSTEIN REFERENCE NO. :: 0471705

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C6-H8-O4

MOLECULAR WEIGHT :: 144.14

WISWESSER LINE NOTATION :: 1OV1U1VO1 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,374,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,Aug,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 530 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg/28D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 29,575,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81813 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 308 (estimated)

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H317-H319-H335-H373
Precautionary Statements	P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P333 + P313-P337 + P313
Target Organs	Skin
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R21/22
Safety Phrases	S23-S36/37
RIDADR	UN 2810
WGK Germany	1
RTECS	EM6300000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29171990

Precursor 10
CAS#:762-42-5 Dimethyl but-2-... CAS#:108-31-6 Maleic anhydride CAS#:1634-04-4 Methyl tert-but... CAS#:67-56-1 Methanol
CAS#:110-16-7 Maleic acid CAS#:141-05-9 diethylmaleate CAS#:106-48-9 4-Chlorophenol CAS#:23652-59-7 4-(pyrrolidin-1...
CAS#:6832-16-2 METHYL DIAZOACETATE CAS#:201230-82-2 carbon monoxide
DownStream 10
CAS#:1104-78-5 2-(Triphenylpho... CAS#:51535-00-3 Methyl 1-benzyl... CAS#:3205-35-4 1,2-Cyclohexane... CAS#:40967-67-7 Trimethyl 1,1,2...
CAS#:24261-13-0 Tetramethyl 1,2... CAS#:5464-22-2 1,1,2,2-Ethanet... CAS#:78453-89-1 Pentamethyl-1,1... CAS#:40853-30-3 hexamethyl buta...
CAS#:38115-87-6 Dimethyl malate CAS#:3152-15-6 3-(4-CHLOROPHEN...

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.

PLoS ONE 9(6) , e98385, (2014)

Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic...

Sensitization to dimethyl fumarate with multiple concurrent patch test reactions.

Contact Dermatitis 62(2) , 88-96, (2010)

Chairs and sofas imported from China to Europe were shown to contain dimethyl fumarate (DMF), a sensitizing, volatile chemical. Many of the sensitized patients also had positive patch test reactions t...

Use of p-nitrophenyl disulfide to measure reductive capacity of intact cells.

Meth. Enzymol. 251 , 279-86, (1995)

EINECS 210-848-5

MFCD00008459

2-Butenedioic acid(2Z)-, 1,4-dimethyl ester

Dimethyl Maleate

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dimethyl maleate

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