(R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯
![(R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯结构式](https://image.chemsrc.com/caspic/075/1268524-71-5.png)
(R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯结构式
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常用名 | (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯 | 英文名 | (-)-JQ-1 |
|---|---|---|---|---|
| CAS号 | 1268524-71-5 | 分子量 | 456.988 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 610.4±65.0 °C at 760 mmHg | |
| 分子式 | C23H25ClN4O2S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 322.9±34.3 °C |
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Targeting bromodomains: epigenetic readers of lysine acetylation.
Nat. Rev. Drug Discov. 13(5) , 337-56, (2014) Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create docking sites for bromodomains, which are small interaction modul... |
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Epigenetic chemical probes. Müller S and Brown PJ
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Targeting chromatin readers. James LI and Frye SV
Clin. Pharmacol. Ther. 93(4) , 312-4, (2013)
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