2,6-二氨基嘌呤
2,6-二氨基嘌呤结构式
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常用名 | 2,6-二氨基嘌呤 | 英文名 | 2,6-Diaminopurine |
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| CAS号 | 1904-98-9 | 分子量 | 150.14 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 749.0±63.0 °C at 760 mmHg | |
| 分子式 | C5H6N6 | 熔点 | 117-122 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 447.8±20.9 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Effect of substituents on the excited-state dynamics of the modified DNA bases 2,4-diaminopyrimidine and 2,6-diaminopurine.
Phys. Chem. Chem. Phys. 12(20) , 5375-88, (2010) To explore the excited state dynamics of pyrimidine derivatives, we performed a combined experimental and theoretical study. We present resonant two-photon ionization (R2PI) and IR-UV double resonance spectra of 2,4-diaminopyrimidine and 2,6-diaminopurine see... |
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Formation and helicity control of ssDNA templated porphyrin nanoassemblies.
Chem. Commun. (Camb.) 49(10) , 1020-2, (2013) We report the formation of left- (M-helix) and right-handed (P-helix) nanoassemblies of a porphyrin-diaminopurine conjugate (Por-DAP) templated by a single stranded oligodeoxythymidine (dT40) via directional hydrogen bonding. The supramolecular helicity can b... |
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Simulations of A-RNA duplexes. The effect of sequence, solute force field, water model, and salt concentration.
J. Phys. Chem. B 116(33) , 9899-916, (2012) We have carried out an extended reference set of explicit solvent molecular dynamics simulations (63 simulations with 8.4 μs of simulation data) of canonical A-RNA duplexes. Most of the simulations were done using the latest variant of the Cornell et al. AMBE... |
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Biotransformation of 2,6-diaminopurine nucleosides by immobilized Geobacillus stearothermophilus.
Biotechnol. Prog. 28(5) , 1251-6, (2012) An efficient and green bioprocess to obtain 2,6-diaminopurine nucleosides using thermophilic bacteria is herein reported. Geobacillus stearothermophilus CECT 43 showed a conversion rate of 90 and 83% at 2 h to obtain 2,6-diaminopurine-2'-deoxyriboside and 2,6... |
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Recombination R-triplex: H-bonds contribution to stability as revealed with minor base substitutions for adenine.
Nucleic Acids Res. 34(11) , 3239-45, (2006) Several cellular processes involve alignment of three nucleic acids strands, in which the third strand (DNA or RNA) is identical and in a parallel orientation to one of the DNA duplex strands. Earlier, using 2-aminopurine as a fluorescent reporter base, we de... |
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Synthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine.
Org. Biomol. Chem. 10(4) , 876-81, (2012) A Boc-protecting group strategy for Fmoc-based PNA (peptide nucleic acid) oligomerization has been developed for thymine, 2,6-diaminopurine (DAP) and 2-aminopurine (2AP). The monomers may be used interchangeably with standard Fmoc PNA monomers. The DAP monome... |
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Density functional and experimental studies on the FT-IR and FT-Raman spectra and structure of 2,6-diamino purine and 6-methoxy purine.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 69(1) , 8-17, (2008) FT-IR and FT-Raman spectra of 2,6-diamino purine (DAP) and 6-methoxy purine (MP) have been recorded in the regions of 4000-400cm(-1) and 3500-100cm(-1), respectively. The spectra were interpreted with the aid of normal coordinate analysis following full struc... |
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Two isomorphous transition metal complexes containing a protonated diaminopurine ligand: diaquabis(2,6-diamino-7H-purin-1-ium-κN9)bis(homophthalato-κO)nickel(II) tetrahydrate and the cobalt(II) analogue.
Acta Crystallogr. C 67(Pt 5) , m169-72, (2011) The two isomorphous title compounds, [M(C(5)H(7)N(6))(2)(C(9)H(6)O(4))(2)(H(2)O)(2)]·4H(2)O or M(2+)(Hdap(+))(2)(hpt(2-))(2)(H(2)O)(2)·4H(2)O {where dap is 2,6-diaminopurine, H(2)hpt is homophthalic acid [2-(2-carboxyphenyl)acetic acid] and M is Ni(II) or Co(... |
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Preparation of the 2'-deoxynucleosides of 2,6-diaminopurine and isoguanine by direct glycosylation.
J. Org. Chem. 75(5) , 1360-5, (2010) The purine nucleoside 2,6-diaminopurine-2'-deoxyriboside is prepared by the direct glycosylation of the 2,6-bis(tetramethylsuccinimide) derivative of the parent purine heterocycle 4 with 2-deoxy-3,5-di-O-(p-toluoyl)-alpha-D-erythro-pentofuranosyl chloride 5 u... |
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RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine.
Nucleic Acids Res. 36(21) , 6806-15, (2008) Sequence-specific recognition of DNA is a critical step in gene targeting. Here we describe unique oligonucleotide (ON) hybrids that can stably pair to both strands of a linear DNA target in a RecA-dependent reaction with ATP or ATPgammaS. One strand of the h... |