菠萝蛋白酶
菠萝蛋白酶结构式
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常用名 | 菠萝蛋白酶 | 英文名 | Ananas comosus |
|---|---|---|---|---|
| CAS号 | 37189-34-7 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | n.a. | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Inhibitory effects of bromelain, a cysteine protease derived from pineapple stem (Ananas comosus), on intestinal motility in mice.
Neurogastroenterol. Motil. 23(8) , 745-e331, (2011) Bromelain (BR) is a cysteine protease with inhibitory effects on intestinal secretion and inflammation. However, its effects on intestinal motility are largely unexplored. Thus, we investigated the effect of this plant-derived compound on intestinal contracti... |
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Trifluoroethanol stabilizes the molten globule state and induces non-amyloidic turbidity in stem bromelain near its isoelectric point.
Int. J. Biol. Macromol. 49 , 536-542, (2011) Stem bromelain (SBM) is a therapeutic protein that has been studied for alkaline denaturation in the intestines, the principal site of its absorption. In this study, we investigated fluorinated alcohol 2,2,2-trifluoroethanol (TFE)-induced conformational chang... |
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Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain.
Arch. Biochem. Biophys. 540(1-2) , 101-16, (2013) Sodium dodecyl sulfate, a biological membrane mimetic, can be used to study the conversion of globular proteins into amyloid fibrils in vitro. Using multiple approaches, the effect of SDS was examined on stem bromelain (SB), a widely recognized therapeutic pr... |
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Purification and characterization of extracellular cysteine protease inhibitor, ECPI-2, from Chlorella sp.
J. Biosci. Bioeng. 101(2) , 166-71, (2006) An extracellular cysteine protease inhibitor (ECPI-2) was purified to homogeneity from the culture filtrate of Chlorella sp. 4533 by the combination of various column chromatographies. The molecular mass of the inhibitor was estimated to be 340 kDa by SDS-PAG... |
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Characterization of different strains of poliovirus and influenza virus by differential scanning calorimetry.
Biotechnol. Appl. Biochem. 41(Pt 3) , 241-6, (2005) Vaccines against poliomyelitis and influenza contain inactivated forms of poliovirus and influenza virus. These antigens are generated on an industrial scale from the purified active viruses that have been analysed in this study by DSC (differential scanning ... |
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Stem bromelain: an enzyme that naturally facilitates oriented immobilization.
Protein Pept. Lett. 14(3) , 233-6, (2007) The lone oligosaccharide chain of stem bromelain was oxidized with periodic acid to generate aldehyde groups and the resulting oxidized enzyme coupled to amino-Sepharose in order to obtain an immobilized preparation with uniformly oriented enzyme. The immobil... |
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Hydrophobic interactions are the prevalent force in bromelain:Fab' complex.
Biochemistry. (Mosc.) 71 Suppl 1 , S31-7, (2006) Antibromelain polyclonal antibodies against stem bromelain were raised in male albino rabbits and the Fab monomers isolated from the IgG of the immune sera as reported in our earlier communication (Gupta, P., Khan, R. H., and Saleemuddin, M. (2003) Biochim. B... |
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Additional stabilization of stem bromelain coupled to a thermosensitive polymer by uniform orientation and using polyclonal antibodies.
Biochemistry. (Mosc.) 72(3) , 307-12, (2007) Stem bromelain was covalently coupled to a thermosensitive polymer of N-isopropylacrylamide (p(NIPAm)) either through the amino groups of the enzyme (randomly coupled) or via the lone oligosaccharide chain (uniformly coupled). The enzyme coupled via the oligo... |
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Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Inflamm. Bowel Dis. 16(12) , 2012-21, (2010) Bromelain, a mixture of proteolytic enzymes typically derived from pineapple stem, decreases production of proinflammatory cytokines and leukocyte homing to sites of inflammation. We previously showed that short-term oral treatment with bromelain purified fro... |
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Stem bromelain-induced macrophage apoptosis and activation curtail Mycobacterium tuberculosis persistence.
J. Infect. Dis. 206(3) , 366-76, (2012) Mycobacterium tuberculosis, the causative agent of tuberculosis, has a remarkable ability to usurp its host's innate immune response, killing millions of infected people annually. One approach to manage infection is prevention through the use of natural agent... |