MMP13-IN-31f
Modify Date: 2025-08-26 20:59:28
MMP13-IN-31f structure
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Common Name | MMP13-IN-31f | ||
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| CAS Number | 935759-55-0 | Molecular Weight | 506.509 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H19FN6O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MMP13-IN-31fMMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM; exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE; prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM). |
| Name | 5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide |
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| Synonym | More Synonyms |
| Description | MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM; exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE; prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM). |
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| References | References 1. Nara H, et al. J Med Chem. 2017 Jan 26;60(2):608-626. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C24H19FN6O4S |
| Molecular Weight | 506.509 |
| Exact Mass | 506.117249 |
| LogP | 2.80 |
| Index of Refraction | 1.727 |
| InChIKey | MLUCCAMJMIYYED-UHFFFAOYSA-N |
| SMILES | O=C(NCc1cccc(OCCOc2ncn[nH]2)c1)c1nc2scc(-c3cccc(F)c3)c2c(=O)[nH]1 |
| 5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide |
| Thieno[2,3-d]pyrimidine-2-carboxamide, 5-(3-fluorophenyl)-3,4-dihydro-4-oxo-N-[[3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]phenyl]methyl]- |