hDHODH-IN-1

Modify Date: 2025-08-30 10:58:44

Use of hDHODH-IN-1

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect[1].

Name	hDHODH-IN-1

Description	hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
In Vitro	Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because DHODH is required to ensure proliferating-cell viability, inhibitors have been developed to eliminate human DHODH (hDHODH) activity, which is associated with cancers, multiple sclerosis, and autoimmune and inflammatory diseases[1].
References	[1]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

Molecular Formula	C₁₇H₁₄N₂O₂
Molecular Weight	278.31
InChIKey	MUVPBAIVOHJDOC-VBKFSLOCSA-N
SMILES	CC(O)=C(C#N)C(=O)Nc1ccc(-c2ccccc2)cc1

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Price: ￥3850/10 mM * 1 mL in DMSO

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