Shanghai Nianxing Industrial Co., Ltd
China
Product Name: hDHODH-IN-2
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: hDHODH-IN-2
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: hDHODH-IN-2
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

183946-00-1

183946-00-1 structure

183946-00-1 structure

Name: hDHODH-IN-2
Chemical Name: hDHODH-IN-2
CAS Number: 183946-00-1
Molecular Formula: C₁₉H₁₆N₂O₂
Molecular Weight: 304.34
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2020-04-08 18:17:48
Modify Date: 2025-09-11 12:34:36
hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

Name	hDHODH-IN-2

Description	hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
In Vitro	hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].
References	[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

Molecular Formula	C₁₉H₁₆N₂O₂
Molecular Weight	304.34

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