hDHODH-IN-2

Modify Date: 2024-01-20 07:58:57

hDHODH-IN-2 structure	Common Name	hDHODH-IN-2
	CAS Number	183946-00-1	Molecular Weight	304.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of hDHODH-IN-2

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

Name	hDHODH-IN-2

Description	hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
In Vitro	hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].
References	[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

Molecular Formula	C₁₉H₁₆N₂O₂
Molecular Weight	304.34

DC Chemicals Limited
China
Product Name: hDHODH-IN-2
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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