MMP13-IN-31f

Names

[ Name ]:
MMP13-IN-31f

[Synonym ]:
5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide
Thieno[2,3-d]pyrimidine-2-carboxamide, 5-(3-fluorophenyl)-3,4-dihydro-4-oxo-N-[[3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]phenyl]methyl]-

Biological Activity

[Description]:

MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM; exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE; prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM).

[References]

References 1. Nara H, et al. J Med Chem. 2017 Jan 26;60(2):608-626. View Related Products by Target Matrix Metalloproteinase (MMP)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₁₉FN₆O₄S

[ Molecular Weight ]:
506.509

[ Exact Mass ]:
506.117249

[ LogP ]:
2.80

[ Index of Refraction ]:
1.727

Related Compounds

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