935759-55-0

935759-55-0 structure

Name: MMP13-IN-31f
Chemical Name: 5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide
CAS Number: 935759-55-0
Molecular Formula: C₂₄H₁₉FN₆O₄S
Molecular Weight: 506.509
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2020-01-13 08:16:49
Modify Date: 2023-01-14 16:07:37
MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM; exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE; prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM).

Name	5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide
Synonyms	5-(3-Fluorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]benzyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide Thieno[2,3-d]pyrimidine-2-carboxamide, 5-(3-fluorophenyl)-3,4-dihydro-4-oxo-N-[[3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]phenyl]methyl]-

Description	MMP13-IN-31f is a highly potent, selective, orally bioavailable MMP-13 inhibitor with IC50 of 0.036 nM; exhibits 5,000-fold selectivity for MMP-13 over MMP-2, >1,500-fold selectivity over MMP-10, and >27,000-fold selectivity over MMP-1, 3, 7, 8, 9, 14, and TACE; prevents IL-1/OSM induced in vitro degradation of BNC (70.8% inhibition of cartilage degradation at 1 µM).
References	References 1. Nara H, et al. J Med Chem. 2017 Jan 26;60(2):608-626. View Related Products by Target Matrix Metalloproteinase (MMP)