α-Conotoxin GI

Modify Date: 2025-08-26 15:04:29

α-Conotoxin GI structure	Common Name	α-Conotoxin GI
	CAS Number	76862-65-2	Molecular Weight	1437.61
	Density	1.71	Boiling Point	N/A
	Molecular Formula	C₅₅H₈₀N₂₀O₁₈S₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of α-Conotoxin GI

α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].

Name	α-CONOTOXIN GI
Synonym	More Synonyms

Description	α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74. [2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235. [3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

References

[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74.

[2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235.

[3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

Density	1.71
Molecular Formula	C₅₅H₈₀N₂₀O₁₈S₄
Molecular Weight	1437.61
Exact Mass	1436.48000
PSA	722.15000
Storage condition	-20°C

α-Conotoxin GI MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GL1500000

CHEMICAL NAME :: Conotoxin GI

CAS REGISTRY NUMBER :: 76862-65-2

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C55-H80-N20-O18-S4

MOLECULAR WEIGHT :: 1437.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 190,539,1978

Hazard Codes	Xn
RIDADR	UN 3172
Packaging Group	III
Hazard Class	6.1(b)

GLU-CYS-CYS-ASN-PRO-ALA-CYS-GLY-ARG-HIS-TYR-SER-CYS-NH2

a-Conotoxin GI

CONOTOXIN GI

a-Conotoxin GI,Conus geographus

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China
Product Name: α-Conotoxin GI
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Purity: 98.0%
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α-Conotoxin GI

Use of α-Conotoxin GI

Names

α-Conotoxin GI Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.