α-Conotoxin MII TFA

Modify Date: 2025-08-26 10:42:29

α-Conotoxin MII TFA Structure
α-Conotoxin MII TFA structure
Common Name α-Conotoxin MII TFA
CAS Number 175735-93-0 Molecular Weight 1710.94000
Density N/A Boiling Point N/A
Molecular Formula C67H103N23O22S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-Conotoxin MII TFA


α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].

 Names

Name α-conotoxin MII
Synonym More Synonyms

 α-Conotoxin MII TFA Biological Activity

Description α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].
Related Catalog
Target

IC50: 0.5 nM (α3β2)[1].

In Vitro α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2].
References

[1]. G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8.

[2]. S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42.

[3]. J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.

 Chemical & Physical Properties

Molecular Formula C67H103N23O22S4
Molecular Weight 1710.94000
Exact Mass 1709.65000
PSA 819.32000

 Synonyms

VU 0155041
Alpha-Conotoxin MII
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