α-Conotoxin MI trifluoroacetate salt
Modify Date: 2025-08-27 09:41:37
α-Conotoxin MI trifluoroacetate salt structure
|
Common Name | α-Conotoxin MI trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 88217-10-1 | Molecular Weight | 1493.72000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H88N22O17S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of α-Conotoxin MI trifluoroacetate saltα-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2]. |
| Name | GRCCHPACGKNYSC-amide, cyclic (3→8),(4→14)-bis(disulfide) |
|---|---|
| Synonym | More Synonyms |
| Description | α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
mAChR[2]; α1β1γδ nAChR[1] |
| In Vitro | α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2]. |
| Molecular Formula | C58H88N22O17S4 |
|---|---|
| Molecular Weight | 1493.72000 |
| Exact Mass | 1492.56000 |
| PSA | 739.97000 |
| alpha-conotoxin MI |
| α-Conotoxin MI trifluoroacetate salt |