α-MSH trifluoroacetate salt

Modify Date: 2024-01-13 11:28:52

α-MSH trifluoroacetate salt structure	Common Name	α-MSH trifluoroacetate salt
	CAS Number	581-05-5	Molecular Weight	1664.884
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₇₇H₁₀₉N₂₁O₁₉S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of α-MSH trifluoroacetate salt

α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

Name	α-Melanocyte stimulating hormone
Synonym	More Synonyms

Description	α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Research Areas >> Metabolic Disease Peptides
Target	Melanocortin 1 receptor[1] Adenylyl cyclase[1]
In Vitro	α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].
In Vivo	α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].
References	[1]. Jo H, et al. Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3374-3377. [2]. Lu XY, et al. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci. 2003 Aug 27;23(21):7863-72.

Density	1.5±0.1 g/cm3
Molecular Formula	C₇₇H₁₀₉N₂₁O₁₉S
Molecular Weight	1664.884
Exact Mass	1663.792969
PSA	668.28000
LogP	-1.77
Index of Refraction	1.682
Storage condition	2-8°C
Water Solubility	Soluble in water (~1 mg/ml).

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	N
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

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PLoS ONE 7(12) , e53111, (2012)

We have previously reported that chemical stimulation of the hypothalamic arcuate nucleus (ARCN) in the rat elicited increases as well as decreases in blood pressure (BP) and sympathetic nerve activit...

N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide

α-Melanocyte Stimulating Hormone

MFCD00133062

L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-

α-MSH