212370-59-7

212370-59-7 structure

Name: Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide trifluoroacetate salt
Chemical Name: hs 024
CAS Number: 212370-59-7
Molecular Formula: C₅₈H₇₉N₁₉O₁₀S₂
Molecular Weight: 1266.499
Catalog: Research Areas Metabolic Disease
Create Date: 2017-08-01 18:55:09
Modify Date: 2024-01-10 23:17:21
HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

Name	hs 024
Synonyms	M.W. 1266.50 C58H79N19O10S2 Neurodazine 1,2-Dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide, 28-(acetylamino)-13,22-bis[3-[[(E)-aminoiminomethyl]amino]propyl]-25-butyl-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenylmethyl)-6,9,12,15,18,21,24,27-octaoxo-, (4R,10S,13S,16R,19S,22S,25S,28R)- AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2 TRIFLUOROACETATE SALT HS024 (4R,10S,13S,16R,19S,22S,25S,28R)-28-Acetamido-25-butyl-13,22-bis(3-carbamimidamidopropyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2

Description	HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
References	[1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.