Nanjing Peptide Biotech Ltd
China
Product Name: α-MSH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-(-)-CITRAMALIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: a-MSH, amide
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

581-05-5

581-05-5 structure

581-05-5 structure

Name: α-MSH trifluoroacetate salt
Chemical Name: α-Melanocyte stimulating hormone
CAS Number: 581-05-5
Molecular Formula: C₇₇H₁₀₉N₂₁O₁₉S
Molecular Weight: 1664.884
Catalog: Biochemical Peptide
Create Date: 2018-09-10 09:36:54
Modify Date: 2024-01-13 11:28:52
α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

Name	α-Melanocyte stimulating hormone
Synonyms	N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide α-Melanocyte Stimulating Hormone MFCD00133062 L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- α-MSH

Description	α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Research Areas >> Metabolic Disease Peptides
Target	Melanocortin 1 receptor[1] Adenylyl cyclase[1]
In Vitro	α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].
In Vivo	α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].
References	[1]. Jo H, et al. Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3374-3377. [2]. Lu XY, et al. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci. 2003 Aug 27;23(21):7863-72.

Density	1.5±0.1 g/cm3
Molecular Formula	C₇₇H₁₀₉N₂₁O₁₉S
Molecular Weight	1664.884
Exact Mass	1663.792969
PSA	668.28000
LogP	-1.77
Index of Refraction	1.682
Storage condition	2-8°C
Water Solubility	Soluble in water (~1 mg/ml).

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	N
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3