76862-65-2

76862-65-2 structure

Name: α-Conotoxin GI
Chemical Name: α-CONOTOXIN GI
CAS Number: 76862-65-2
Molecular Formula: C₅₅H₈₀N₂₀O₁₈S₄
Molecular Weight: 1437.61
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2018-11-26 19:45:50
Modify Date: 2025-08-26 15:04:29
α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].

Name	α-CONOTOXIN GI
Synonyms	GLU-CYS-CYS-ASN-PRO-ALA-CYS-GLY-ARG-HIS-TYR-SER-CYS-NH2 a-Conotoxin GI CONOTOXIN GI a-Conotoxin GI,Conus geographus

Description	α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74. [2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235. [3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 190,539,1978