NS 3763
NS 3763 structure
|
Common Name | NS 3763 | ||
|---|---|---|---|---|
| CAS Number | 70553-45-6 | Molecular Weight | 404.37200 | |
| Density | 1.485g/cm3 | Boiling Point | 490.7ºC at 760 mmHg | |
| Molecular Formula | C22H16N2O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.6ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of NS 3763NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1]. |
| Name | 4,6-dibenzamidobenzene-1,3-dicarboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.6 µM (GLUK5 receptor)[1] |
| In Vitro | In human embryonic kidney HEK293 cells expressing homomeric GLUK5 or GLUK6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC50 = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC50 > 30 µM)[1]. NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLUK5 receptors in HEK293 cells[1]. |
| References |
| Density | 1.485g/cm3 |
|---|---|
| Boiling Point | 490.7ºC at 760 mmHg |
| Molecular Formula | C22H16N2O6 |
| Molecular Weight | 404.37200 |
| Flash Point | 250.6ºC |
| Exact Mass | 404.10100 |
| PSA | 132.80000 |
| LogP | 3.73360 |
| Index of Refraction | 1.735 |
| InChIKey | UUDYZUDTQPLDDP-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cc(NC(=O)c2ccccc2)c(C(=O)O)cc1C(=O)O)c1ccccc1 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H410 |
| Precautionary Statements | P261-P273-P305 + P351 + P338-P501 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi,N |
| Risk Phrases | 36/37/38-50/53 |
| Safety Phrases | 26-36-60-61 |
| RIDADR | UN 3077 9/PG 3 |
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Neurotoxic effects of TDP-43 overexpression in C. elegans.
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| NS3763 |
| 5-Carboxy-2,4-dibenzamidobenzoic acid |