DC Chemicals Limited
China
Product Name: NS3763
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,6-BIS(BENZOYLAMINO)-1,3-BENZENEDICARBOXYLIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

70553-45-6

70553-45-6 structure

70553-45-6 structure

Name: NS 3763
Chemical Name: 4,6-dibenzamidobenzene-1,3-dicarboxylic acid
CAS Number: 70553-45-6
Molecular Formula: C₂₂H₁₆N₂O₆
Molecular Weight: 404.37200
Create Date: 2018-12-25 12:31:46
Modify Date: 2024-01-05 09:14:28
NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1].

Name	4,6-dibenzamidobenzene-1,3-dicarboxylic acid
Synonyms	NS3763 5-Carboxy-2,4-dibenzamidobenzoic acid

Description	NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	IC50: 1.6 µM (GLUK5 receptor)[1]
In Vitro	In human embryonic kidney HEK293 cells expressing homomeric GLUK5 or GLUK6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC50 = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC50 > 30 µM)[1]. NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLUK5 receptors in HEK293 cells[1].
References	[1]. Jeppe K Christensen, et al. In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J Pharmacol Exp Ther. 2004 Jun;309(3):1003-10.

Density	1.485g/cm3
Boiling Point	490.7ºC at 760 mmHg
Molecular Formula	C₂₂H₁₆N₂O₆
Molecular Weight	404.37200
Flash Point	250.6ºC
Exact Mass	404.10100
PSA	132.80000
LogP	3.73360
Index of Refraction	1.735

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H335-H410
Precautionary Statements	P261-P273-P305 + P351 + P338-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi,N
Risk Phrases	36/37/38-50/53
Safety Phrases	26-36-60-61
RIDADR	UN 3077 9/PG 3