NS 3763
NS 3763 structure
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Common Name | NS 3763 | ||
|---|---|---|---|---|
| CAS Number | 70553-45-6 | Molecular Weight | 404.37200 | |
| Density | 1.485g/cm3 | Boiling Point | 490.7ºC at 760 mmHg | |
| Molecular Formula | C22H16N2O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.6ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.
Mol. Cell. Biol. 29 , 3881-93, (2009) In Caenorhabditis elegans, the central cell-killing process is essentially controlled by the interplay of four apoptotic factors: EGL-1/BH3-only protein, CED-9/Bcl2, CED-4/Apaf1, and CED-3/caspase. In cells destined to die, EGL-1 binds to CED-9 and results in... |
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Neurotoxic effects of TDP-43 overexpression in C. elegans.
Hum. Mol. Genet. 19 , 3206-18, (2010) RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, w... |
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Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
J. Cell Biol. 124 , 1510-8, (2011) Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the... |
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MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.
Development 136 , 2223-34, (2009) Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are av... |
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In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.
J. Pharmacol. Exp. Ther. 309 , 1003-1010, (2004) Accumulating preclinical data suggest that compounds that block the excitatory effect of glutamate on the kainate subtype of glutamate receptors may have utility for the treatment of pain, migraine, and epilepsy. In the present study, the in vitro pharmacolog... |
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Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53.
Dev. Biol. 344 , 1011-25, (2010) Proliferating germ cells in Caenorhabditiselegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling, we identified approximately 200 genes upr... |
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The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.
PLoS ONE 4 , e7450, (2009) The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, th... |