[Nle11]-Substance P

Modify Date: 2025-08-24 01:10:13

[Nle11]-Substance P structure	Common Name	[Nle11]-Substance P
	CAS Number	57462-42-7	Molecular Weight	1329.592
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₄H₁₀₀N₁₈O₁₃	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of [Nle11]-Substance P

[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

Name	arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2
Synonym	More Synonyms

Description	[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
In Vitro	Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1].
References	[1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

Density	1.4±0.1 g/cm3
Molecular Formula	C₆₄H₁₀₀N₁₈O₁₃
Molecular Weight	1329.592
Exact Mass	1328.771729
PSA	516.63000
LogP	-0.18
Index of Refraction	1.654

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Boc-Gly-OH

CAS#:4530-20-5

Boc-Leu-OH.H2O

CAS#:13139-15-6

Boc-L-phenylalanine

CAS#:13734-34-4

N-Boc-L-Norleucine

CAS#:6404-28-0

Detail

Literature: Journal of Medicinal Chemistry, , vol. 25, # 1 p. 64 - 68

Precursor 4
CAS#:4530-20-5 Boc-Gly-OH CAS#:13139-15-6 Boc-Leu-OH.H2O CAS#:13734-34-4 Boc-L-phenylalanine CAS#:6404-28-0 N-Boc-L-Norleucine
DownStream 0

In vitro activities of some synthetic substance P analogs.

Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979)

Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP...

Synthesis and biological activities of photoaffinity labeling analogues of substance P.

J. Med. Chem. 25 , 470, (1982)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin...

Some observations indicating a low brain uptake of [3H]Nle11-Substance P.

Pharmazie 38(2) , 108-10, (1983)

The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in...

L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-

substance P,NleNH2(11)

N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide

Substance P,[Nle11]

[Nle11 ]-substance P

N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide

[Nle11]-Substance P

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China
Product Name: [Nle11]-Substance P ≥97%
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China
Product Name: (Nle11)-Substance P
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Purity: 98.0%
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[Nle11]-Substance P

Use of [Nle11]-Substance P

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[Nle11]-Substance P Biological Activity

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Precursor & DownStream

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Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.