89430-34-2

89430-34-2 structure

Name: [D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)
Chemical Name: [D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)
CAS Number: 89430-34-2
Molecular Formula: C₅₈H₇₇N₁₃O₁₀
Molecular Weight: 1116.31000
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-10-10 19:16:34
Modify Date: 2024-01-12 14:49:18
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP)[1].

Name	[D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)
Synonyms	4-Pro-7,9-Trp-11-nle-substance p (4-11) substance P (4-11),Pro(4)-Trp(7,9)-Nle(11) Substance P,fragment 4-11,[D-Pro4,D-Trp7,9,Nle11] (D-pro4,D-trp7,9,nle11)-substance P*fragment 4-11 Pttnl-sp(4-11) H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2 SUBSTANCE P [D-PRO4,D-TRP7,9,NLE11]-FRAGMENT 4-11 D-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Nle-NH2 (D-PRO4,D-TRP7,9,NLE11)-SUBSTANCE P (4-11) D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2

Description	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) (100 nM) dose not exert a direct relaxant or contractile effect, but significantly reduces the vasodilatation induced by SP and GPSP[1].
References	[1]. Cathieni M M, et al. Pharmacological Evidence that Gold-Protein-Substance P Complex Activates Neurokinin NK1 Receptors[J]. Cellular Physiology & Biochemistry, 1995, 5(2):85-95.

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