Shanghai Nianxing Industrial Co., Ltd
China
Product Name: [Nle11]-Substance P ≥97%
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Nanjing Peptide Biotech Ltd
China
Product Name: (Nle11)-Substance P
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

57462-42-7

57462-42-7 structure

57462-42-7 structure

Name: [Nle11]-Substance P
Chemical Name: arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2
CAS Number: 57462-42-7
Molecular Formula: C₆₄H₁₀₀N₁₈O₁₃
Molecular Weight: 1329.592
Catalog: Peptides
Create Date: 2019-01-09 11:33:28
Modify Date: 2025-08-24 01:10:13
[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

Name	arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2
Synonyms	L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- substance P,NleNH2(11) N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide Substance P,[Nle11] [Nle11 ]-substance P N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide [Nle11]-Substance P

Description	[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
In Vitro	Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1].
References	[1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

Density	1.4±0.1 g/cm3
Molecular Formula	C₆₄H₁₀₀N₁₈O₁₃
Molecular Weight	1329.592
Exact Mass	1328.771729
PSA	516.63000
LogP	-0.18
Index of Refraction	1.654

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

4530-20-5 structure

4530-20-5

13139-15-6 structure

13139-15-6

13734-34-4 structure

13734-34-4

6404-28-0 structure

6404-28-0

~%

Detail

Literature: Journal of Medicinal Chemistry, , vol. 25, # 1 p. 64 - 68

Precursor 4
4530-20-5 13139-15-6 13734-34-4 6404-28-0
DownStream 0

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