[Nle11]-Substance P
![[Nle11]-Substance P Structure](https://image.chemsrc.com/caspic/019/57462-42-7.png)
[Nle11]-Substance P structure
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Common Name | [Nle11]-Substance P | ||
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| CAS Number | 57462-42-7 | Molecular Weight | 1329.592 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C64H100N18O13 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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In vitro activities of some synthetic substance P analogs.
Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979) Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP(4--11) greater than SP = [Tyr7]-SP = [Eth11]-SP = [Nle11]-... |
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Synthesis and biological activities of photoaffinity labeling analogues of substance P.
J. Med. Chem. 25 , 470, (1982) Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-acting analogues of this peptide hormone are known to date. In o... |
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Some observations indicating a low brain uptake of [3H]Nle11-Substance P.
Pharmazie 38(2) , 108-10, (1983) The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after intracarotid injection of [3H] Nle11-SP or [14C] inulin was d... |
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In vitro degradation of substance P: new rapid assay and distribution in rat brain.
Acta Biol. Med. Ger. 40(6) , 779-84, (1981) An ion exchange batchwise procedure was developed for the estimation of substance P degradation by rat brain fractions using 3H[Nle11]substance P as tracer. With this very sensitive and rapid method an especially high degradative activity was found among othe... |