Acta biologica et medica Germanica 1981-01-01

In vitro degradation of substance P: new rapid assay and distribution in rat brain.

T N Akopyan, H Berger, B Mehlis, P Oehme, A A Galoyan

Index: Acta Biol. Med. Ger. 40(6) , 779-84, (1981)

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Abstract

An ion exchange batchwise procedure was developed for the estimation of substance P degradation by rat brain fractions using 3H[Nle11]substance P as tracer. With this very sensitive and rapid method an especially high degradative activity was found among others in the microsomal fractions of the striatum.