4-Quinazolinone

Modify Date: 2025-08-21 02:22:03

4-Quinazolinone structure	Common Name	4-Quinazolinone
	CAS Number	491-36-1	Molecular Weight	146.146
	Density	1.3±0.1 g/cm3	Boiling Point	324.8±15.0 °C at 760 mmHg
	Molecular Formula	C₈H₆N₂O	Melting Point	216-219 °C(lit.)
	MSDS	N/A	Flash Point	150.2±20.4 °C

Use of 4-Quinazolinone

4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities[1][2].

Name	4-Hydroxyquinazoline
Synonym	More Synonyms

Description	4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cancer Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Research Areas >> Infection Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
References	[1]. Jafari E, et al. Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities. Res Pharm Sci. 2016 Jan-Feb;11(1):1-14. [2]. Hameed A, et al. Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011-2016). Expert Opin Ther Pat. 2018 Apr;28(4):281-297.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Cancer

Research Areas >> Endocrinology

Research Areas >> Inflammation/Immunology

Research Areas >> Infection

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

References

[1]. Jafari E, et al. Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities. Res Pharm Sci. 2016 Jan-Feb;11(1):1-14.

[2]. Hameed A, et al. Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011-2016). Expert Opin Ther Pat. 2018 Apr;28(4):281-297.

Density	1.3±0.1 g/cm3
Boiling Point	324.8±15.0 °C at 760 mmHg
Melting Point	216-219 °C(lit.)
Molecular Formula	C₈H₆N₂O
Molecular Weight	146.146
Flash Point	150.2±20.4 °C
Exact Mass	146.048019
PSA	45.75000
LogP	0.30
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.705
Storage condition	Desiccate at RT

4-Quinazolinone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA2300000

CHEMICAL NAME :: 4(3H)-Quinazolinone

CAS REGISTRY NUMBER :: 491-36-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H6-N2-O

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: T66 BVM ENJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 609 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S37/39-S36/37/39-S22
WGK Germany	3
RTECS	VA2300000
HS Code	29335995

Precursor 10
CAS#:50-00-0 Formaldehyde CAS#:28144-70-9 Benzenecarboxim... CAS#:134-20-3 Methyl 2-aminob... CAS#:149-73-5 Trimethyl ortho...
CAS#:118-48-9 Isatoic anhydride CAS#:122-51-0 Triethyl orthof... CAS#:64-18-6 Formic Acid CAS#:1885-29-6 aminobenzonitrile
CAS#:118-92-3 Anthranilic acid CAS#:77287-34-4 (Z)-Methanimidi...
DownStream 10
CAS#:108664-34-2 3-[3-(4-chlorop... CAS#:108664-81-9 2-(4-chlorophen... CAS#:108086-38-0 2-(4-oxoquinazo... CAS#:110287-93-9 2,4-diphenyl-1H...
CAS#:108086-43-7 N-(3-nitropheny... CAS#:108086-41-5 N-(3-methoxyphe... CAS#:108086-42-6 N-(2-nitropheny... CAS#:108664-35-3 3-[3-(4-methoxy...
CAS#:108086-40-4 N-(4-methoxyphe... CAS#:108664-54-6 3-[1-(4-chlorop...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MFCD00511302

Quinazolone,4

3,4-Dihydro-4-oxoquinazoline

QUINAZOLONE

T66 BVN EMJ

QUINAZOLIN-4-OL

4-oxo-3,4-dihydroquinazoline

T66 BVM ENJ

4-QUINAZOLINO

4(3H)-Quinazolinone

3,4-dihydroquinazolin-4-one

quinazolin-4(3H)-one

3H-quinazolinyl-4-one

quinazoline-4(3H)-one

4-QUINAZOLONE

4-Quinazolinol

T66 BN DNJ EQ

EINECS 207-735-8

4-Hydroxyquinazoline

Quinazolin-4-one

4(1H)-Quinazolinone

QUINAZOLINONE

4-HQN

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Quinazolinone
Price: Check
Purity: 98.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Quinazolinone
Price: ￥108.0/25g ￥298.0/100g
Purity: 97.0%
Delivery: Inquiry
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DC Chemicals Limited
China
Product Name: 4-Hydroxyquinazoline;Quinazolin-4-ol, 4-Quinazolinol
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 4-Hydroxyquinazoline;Quinazolin-4-ol, 4-Quinazolinol
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxyquinazoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 4-Quinazolinone
Price: ￥Inquiry/25kg
Purity: 98.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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4-Quinazolinone suppliers

Price: ￥550/10 mM * 1 mL in DMSO

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4-Quinazolinone

Use of 4-Quinazolinone

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4-Quinazolinone Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Precursor & DownStream

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